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Low Glutathione Levels in Patients Scientific studies have observed that individuals with chronic skin challenges often have significantly lower levels of glutathione in their blood and skin tissue compared to those without these concerns

Abbreviations AAb+: Autoantibody positive AFM: Afamin ApoB: Apolipoprotein B-100 ApoC1: Apolipoprotein C1 ApoL1: Apolipoprotein L1 BMI-SDS: BMI expressed as standard deviation score CETP: Cholesteryl ester transfer protein F2: Prothrombin FDR: False discovery rate GPx: Glutathione peroxidase GPX3: Glutathione peroxidase 3 GSH: Glutathione HGFAC: Hepatocyte growth factor activator HRG: Histidine-rich glycoprotein IGFBP1: IGF-binding protein 1 IGFBP2: IGF-binding protein 2 IGFBP3: IGF-binding protein 3 INNODIA: Innovative approaches to understanding and arresting type 1 diabetes LMM: Linear mixed effects model MASP2: MBL associated serine protease 2 MMTT: Mixed meal tolerance test ND: Newly diagnosed with type 1 diabetes PPAR: Peroxisome proliferator-activated receptor QC: Quality control Se: Selenium SERPING1: Plasma protease C1 inhibitor SRM: Selected reaction monitoring TGFBI: TGF--induced protein ig-h3 TTR: Transthyretin UFM: Unaffected family member References Rodriguez-Calvo T, Richardson SJ, Pugliese A (2018) Pancreas pathology during the natural history of type 1 diabetes

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Third, additional real-world effectiveness data are urgently needed to complement trial findings and assess outcomes in more diverse populations (146)

Food Bioscience, 61 (104545), 118